Low Magnesium Tied to Depression, Migraines, and Alzheimer’s.

Magnesium is far more than a mineral—it’s a crucial brain-and-mood regulator. A 2025 comprehensive review in Nutrients by Varga et al. shows that low magnesium is linked to depression, migraine, Alzheimer’s, and cognitive decline through its role in neurotransmitter balance (serotonin, GABA, glutamate), stress hormones, and reducing inflammation and oxidative stress.

In migraine, magnesium helps regulate blood flow and neuronal excitability, easing vascular tension. In mood disorders, it stabilizes stress-response circuits, calming overactive brain signals. And in Alzheimer’s, magnesium’s neuroprotective and anti-inflammatory effects may slow disease progression.

Check your diet—and if you’re low, consider supplementing with 200–400 mg of magnesium glycinate or citrate daily. Your brain, mood, and memory may depend on it.