In 2025, Kuan-Hung Lin and team from Taipei Medical University studied 60 adults with frequent alcohol-related headaches. In a 4-week trial, half got 100 mg daily vitamin B1 (thiamine), while others received a placebo. They measured headache frequency, blood flow via ultrasound, and brain cell health through blood markers, adjusting for alcohol intake and age.

Magnesium is far more than a mineral—it’s a crucial brain-and-mood regulator. A 2025 comprehensive review in Nutrients by Varga et al. shows that low magnesium is linked to depression, migraine, Alzheimer’s, and cognitive decline.

A 2025 pilot study from the University of Naples “Federico II” found that the diabetes drug liraglutide (a GLP-1 receptor agonist) reduced monthly migraine days by over 50% in patients with chronic migraine.