In 2023, Mark Hyman from the UltraWellness Center reviewed research on mitochondria, the cell powerhouses that convert food to energy. They decline with age, causing fatigue, brain fog, muscle weakness, and inflammation linked to diseases like Parkinson's, diabetes, heart disease, and cancer. Exercise triggers mitophagy, clearing damaged mitochondria, with studies showing 20-30% better mitochondrial function in active people vs. sedentary.

In 2025, Jianyong Wu and Yanni Cao from Ohio State University analyzed data from over 66,000 US census tracts, comparing life expectancy based on proximity to water. They looked at coastal areas (oceans/gulfs within 30 miles) vs. inland rivers/lakes, factoring in urban/rural settings, to see if "blue spaces" affect how long people live.

In 2025, Kosuke Kato and team from Emory University studied psilocin, the active compound in magic mushrooms, in human cells and 19-month-old mice (equivalent to ~60-year-old humans). They treated cells with psilocin and gave mice monthly psilocybin doses for weeks, measuring cell lifespan, mouse survival, and aging signs like fur condition.

A 2025 study analyzing 85 previous studies found that people who stay consistently active have a 30–40% lower risk of early death—especially from heart disease. Even those who start exercising later in life still see a 20–25% drop in mortality risk, showing it’s never too late to change your future.

A 2024 study from Tufts University published in The Journal of Nutrition found that drinking 1–3 cups of black coffee per day was linked to a 14–17% lower risk of death from any cause, including cardiovascular disease. But when that coffee is loaded with sugar or saturated fat, the benefit fades fast.