Running Literally Rewires Your Brain to Fight Alzheimer’s.

A 2024 study by Mass General Brigham found that exercise doesn’t just help memory—it actually activates specific genes that protect against Alzheimer’s. Mice with Alzheimer’s who used running wheels showed better memory, and scientists found that their brains had boosted activity in cells tied to blood vessels and immune defense. They even discovered a new cell type called NVA astrocytes that may play a critical role.

Researchers used advanced RNA sequencing to map changes in each brain cell type. The study revealed that a gene called Atpif1 helps stimulate the growth of new neurons. To make sure it applies to humans, the team compared their results to human Alzheimer’s brain tissue—and the patterns matched.

This was an animal study, using a mouse model of Alzheimer’s. While powerful for understanding mechanisms, animal studies don’t always guarantee the same results in humans. But validating the findings in human brain tissue strengthens its credibility.

Daily movement—especially running—is a no-brainer.