High-Phenolic Extra Virgin Olive Oil Boosts Heart Health.

In 2025, Christos Kourek and team conducted a single-blind randomized clinical trial with 50 hyperlipidemic patients and 20 healthy controls at the General Hospital of Messinia, Greece. Patients were assigned to either 20g/day lower-phenolic EVOO or 8g/day higher-phenolic EVOO for 4 weeks. Lipid profiles were measured at baseline and post-intervention.

Higher-phenolic EVOO (Group 2) reduced total cholesterol more effectively than lower-phenolic EVOO. Both groups showed increased HDL and reduced Lp(a) compared to controls, with no significant gender differences. The higher polyphenol-to-lipid ratio likely enhanced absorption, boosting efficacy.

Consume 8-20g/day high-phenolic EVOO (≥400 mg/kg) to improve cholesterol and reduce cardiovascular risk.