Not Just Hot Flashes—Early Menopause Hides a Depression Epidemic.

A 2025 cross-sectional observational study of nearly 350 women with premature ovarian insufficiency (POI) revealed that almost 30% experienced depressive symptoms, far higher than the general population—highlighting a hidden mental health crisis linked to early menopause.

The study found that younger age at diagnosis, severe menopause symptoms, grief over fertility loss, and lack of emotional support were key drivers of depression. Surprisingly, hormone therapy made no difference in mood, and night sweats were not associated with depressive symptoms—hinting that psychosocial factors, not just hormonal changes, are at play.

Women facing early menopause need more than estrogen—they need mental health support, grief counseling, and community connection. Screening for depression should be routine, and care plans must treat both mind and body.