In 2025, Sandhya P Chakravartti and colleagues examined 75 young adults in a crossover trial. Sucralose (vs. sugar or water) spiked hypothalamic blood flow by 10-20%, boosted hunger by 15%, and strengthened brain connections for craving and sensing, potentially leading to overeating. Other studies (2022, 2023) showed sucralose alters gut bacteria, increasing glucose intolerance (10-15% worse in mice) and metabolic issues like inflammation.