4:3 Intermittent Fasting Curbs Hunger During Weight Loss.

In 2025, Matthew J. Breit and a team from the University of Colorado Anschutz Medical Campus did a secondary look at a 12-month trial with 36 adults trying to lose weight. They compared two groups: one cut calories every day, the other did 4:3 intermittent fasting (normal eating 4 days, low calories 3 days). They tracked eating habits, hunger feelings, and hormones like ghrelin (hunger signal) and leptin (fullness signal) at start, 3 months, and 12 months using surveys and blood tests.

The fasting group felt less hungry and more full after meals by 20-30% compared to constant calorie cutters, with better control over eating urges. But hormones didn't change much—ghrelin dropped similarly in both (10-15% less), and leptin stayed steady. Fasting helped lose 10-15% body weight, matching the other group, without raising binge risks.

Try 4:3 intermittent fasting during weight loss to feel less hungry and stay on track.